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Wen-Li Hsu , Ph.D.
Assistant Investigator




+886-7-3121101 ext. 2326

Research Interests


博士 Sc.D.

日本早稻田大學, 先進理工學部

Sc.D., Waseda University, Graduate School of Advcanced Science and Engineering

碩士 M.S.

中山醫學大學, 醫學分子毒理所

Chung Shan Medical University, School of Medicine Department: Institute of Medical and Molecular Toxicology



國家衛生研究院, 高齡醫學暨健康福祉研究中心

Assistant Investigator
National Center for Geriatrics and Welfare Research, National Health Research Institutes, Taiwan



Adjunct Assistant Research Fellow
Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University



Assistant Research Fellow
Kaohsiung Municipal Ta-Tung Hospital,
Kaohsiung Medical University Hospital, Kaohsiung Medical University



Adjunct Researcher
Research Organization for Nano & Life Innovation, Waseda University


  • “Close the aging initiator, restart your youth factor!”-Honorable Mention of 15th ZHAN GUO CE 2020, Taiwan
  • Judges’ list award of From IP to IPO, FITI 2020, Taiwan
  • The founder of Chromics Biotechnology Co., Ltd. Honored with Outstanding Entrepreneurship Award in the Manufacture Industry of the 2019 U-start Plan for Innovation and Entrepreneurship
  • Award of National Innovation Competition 2019, Kaohsiung Medical University
  • “Derinat, deoxyribonucleic acid salt, for treating hair loss and hair growth”-the best innovative invention of 2018 Taiwan Innotech Expo


  1. Pro-USA, 105006-US-PRO (2017~2018)
    Composition and method for treating hair loss and hair growth
  2. Taiwan, (I715838, 2021~)
    Use of a composition in the manufacture of medicaments for promoting hair growth, preventing hair loss or promoting the proliferation of hair growth or promoting the proliferation of hair follicle stem cells in a subject.
  3. PCT, Japan (No. 6996775, 2022~)
    Use of a composition in the manufacture of medicaments for promoting hair growth, preventing hair loss or promoting the proliferation of hair growth or promoting the proliferation of hair follicle stem cells in a subject.
  4. Taiwan (I802236, 2023~)
    9,12-octadecadiynoic acid to promote neurodevelopment of infants and young children.


  1. Shin-Huei Kuo#, Wen-Li Hsu#, Ching-Ying Wu, Yu-Chang Lai, Tun-Chieh Chen*. Dolutegravir-induced growth and lifespan effects in Caenorhabditis elegans. BMC Pharmacology and Toxicology, (2023) 24:74. (# First author).
  2. Ching-Ying Wu, Wei-Chiao Chen, Cheng-Hsu Hsieh, Yun-Fang Liang, Wei-Ju Li, Hao Shen, Wei-Yen Wei, Ting-Yu Chou, Yen-Chun Chiu, Hao Huang, Wen-Li Hsu*. Efficacy of Derinat as a Treatment for Murine and Androgenetic Alopecia (AGA) Patients. Translational Medicine Communications, (2023) 8:25.
  3. Chih-Yi Ho, Jeff Yi-Fu Chen, Wen-Li Hsu, Sebastian Yu, Wei-Chiao Chen, Szu-Hao Chiu, Hui-Ru Yang, Sheng-Yao Lin and Ching-Ying Wu*. Female Pattern Hair Loss: An Overview with Focus on the Genetics. Genes, 23;14(7):1326.
  4. Hui-Kan Su, Wei-Chao Chen, Jian-He Lu, How-Ran Chao, Yun-Fang Liang, Haruka, Sato, Wen-Li Hsu*, Mei-Li Wu*, Ming-Hsien Tsai*. The effects of using Tempeh as supplement for Type II diabetes. Food Science and Nutrition, 2023, 00:1–9. (* Corresponding author)
  5. Tun-Chieh Chen, Wen-Li Hsu, Ching-Ying Wu, Yun-Ru Lai, How-Ran Chao, Chu-Huang Chen and Ming-Hsien Tsai*. Effect of omega-6 Linoleic Acid on Neurobehavioral Development in Caenorhabditis elegans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2023, 191: 102557.
  6. Chia-Hsiu Wu#, Wen-Li Hsu#, Ching-Chung Tsai, How-Ran Chao, Ching-Ying Wu, Yi-Hsuan Chen, Yun-Ru Lai, Chu-Huang (Mendel) Chen, Ming-Hsien Tsai*. 7,10,13,16-Docosatetraenoic Acid Restrains Neurobehavioral Development Related to an Increase of Reactive Oxidative Species Production in Caenorhabditis Elegans. Life Science, 2023, 319: 121500. (# First author)
  7. Jui-Lin Liang, Ming-Hsien Tsai, Yi-Chun Hsieh, Shao-Wei Chen, Yung-Yun Huang, Li-Ching Lin, Tsung-Fu Tsai, Wen-Li Hsu. Transient receptor potential canonical 7 (TRPC7) facilitates cell growth and migration by regulating intracellular Ca2+ mobilization in lung adenocarcinoma cells. Oncology Letters, 2023, 25(3):92.
  8. Wei-Chiao Chen#, Wen-Li Hsu#, Ching-Ying Wu. Second-to-fourth digit ratio and age predicting the severity of androgenetic alopecia: A cross-sectional study. The Aging Male, 2022, 25(1):242-248. (# First author)
  9. Ming-Hsien Tsai, How-Ran Chao*, Wen-Li Hsu*, Ching-Chung Tsai, Chu-Wen Lin and Chu-Huang Chen. Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment. J. Environ. Res. Public Health, 2021, 18(21):11501. (* Corresponding author)
  10. Wen-Li Hsu, Mami Noda, Tohru Yoshioka, Etsuro Ito. A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression. Exploration of Targeted Anti-tumor Therapy, 2021, 2(5):401–415. (First author)
  11. Tun-Chieh Chen, How-Ran Chao, Ching-Ying Wu, Yun-Ru Lai, Chu-Huang Chen, Tohru Yoshioka, Wen-Li Hsu* and Ming-Hsien Tsai*. Effect of 9,12-Octadecadiynoic Acid on Neurobehavioral Development in Caenorhabditis elegans. Int. J. Mol. Sci., 2021, 22(16):8917. (* Corresponding author)
  12. Wen-Li Hsu, Yi-Chun Hsieh, Hsin-Su Yu, Tohru Yoshiok, Ching-Ying Wu. 2-Aminoethyl diphenylborinate inhibits bleomycin-induced skin and pulmonary fibrosis via interrupting intracellular Ca2+ regulation. Journal of Dermatological Science, 2021, 103(2):101-108. (First author)
  13. Kai-Wei Tang#, Wen-Li Hsu#, Cheng-Ru Chen, Ming-Hsien Tsai, Chia-Jung Yen, Chih-Hua Tsenga. Discovery of triazolyl thalidomide derivatives as anti-fibrosis agents. New Journal of Chemistry, 2021, 45(3):3589. (# First author)
  14. Ming-Hsien Tsai, How-Ran Chao, Jheng-Jie Jiang, Yu-Hsieh Su,Mariene-syne P. Cortez, Lemmuel L. Tayo, I-Cheng Lu, Hao Hsieh, ChihChung Lin, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang, Wen-Li Hsu. Toxicity of Low-dose Graphene Oxide Nanoparticles in an in-vivo Wild Type of Caenorhabditis elegans Model. Aerosol and Air Quality Research. 2021, 21(5):200559
  15. Wen-Li Hsu, Ming-Hsien Tsai, Ching-Ying Wu, Jui-Lin Liang, Jian-He Lu, Jennifer S. Kahle, Hsin-Su Yu, Chia-Jung Yen, Chen-Tung Yen, Yung-Yun Huang, Li-Ching Lin, Tsung-Fu Tsai, Chu-Huang Chen, Tohru Yoshioka. Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by UVB. Aging Cell, 2020, 19(1):e13075. (First author)
  16. Meng-Ching Chung, Ming-Hsien Tsai, Danielle E. Que, Sayre J. Bongo, Wen-Li Hsu, Lemmuel L. Tayo, Yi-Hsien Lin, Sheng-Lun Lin, Yan-You Gou, Yi-Chyun Hsu, Wen-Che Hou, Kuo-Lin Huang, How-Ran Chao. Fine particulate matter-induced toxic effects in an animal model of Caenorhabditis elegans. Aerosol and Air Quality Research, 2019, 19(5):1068-1078.
  17. Cheng-Chih Kao, Danielle E. Que, Sayre J. Bongo, Lemmuel L. Tayo, Yi-Hsien Lin, Chun-Wen Lin, Sheng-Lun Lin, Yan-You Gou, Wen-Li Hsu, Cherng-Gueih Shy, Kuo-Lin Huang, Ming-Hsien Tsai, How-Ran Chao. Residue levels of organochlorine pesticides in breast milk and the potential effects on cord blood thyroid hormones and the offspring’s neurodevelopment. J. Environ. Res. Public Health, 2019, 16(8):1438.
  18. Che-Mai Chang, Henry Sung-Ching Wong, Chien-Yu Huang, Wen-Li Hsu, Ben-Kuen Chen, Siou-Jin Chiu, Yao-Ting Tsai, Jaw-Yuan Wang, Wei-Chiao Chang. Functional Effects of let-7g Expression in Colon Cancer Metastasis. Cancers, 2019, 11(4):489.
  19. Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Chee-Yin Chai, Chia-Jung Yen, Chu-Huang Chen, Jian-He Lu, Hsin-Su Yu, Tohru Yoshioka. A potential new approach for treating systemic sclerosis: dedifferentiation of SSc fibroblasts and change in the microenvironment by blocking store-operated Ca2+ entry. PLOS ONE, 2019, 14(2019): e0213400.
  20. Yu‐Chen Wang, An‐Sheng Lee, Long‐Sheng Lu, Liang‐Yin Ke, Wei‐Yu Chen, Jian‐Wen Dong, Jonathan Lu, Zhenping Chen, Chih‐Sheng Chu, Hua‐Chen Chan, Taha Y. Kuzan, Ming‐Hsien Tsai, WenLi Hsu, Richard A. F. Dixon, Tatsuya Sawamura, Kuan‐Cheng Chang, Chu‐Huang Chen (2018, Jun). Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. Aging Cell, 2018, 17(4):e12792.
  21. Ping-Ching Wu#, Wen-Li Hsu#, Chun-Lin Chen, Chen-Fuh Lam, Yaw-Bin Huang, Chien-Chi Huang, Ming-Hong Lin, Ming-Wei Lin (2018, Mar). Morphine Induces Fibroblast Activation through Up-regulation of Connexin 43 Expression: Implication of Fibrosis in Wound Healing. J. Med. Sci., 2018, 15(9):875-882. (# First author)
  1. The role of transient receptor potential canonical 7 (TRPC7) in western diet-induced aortic damage via abnormal lipid production. Wen-Li Hsu, Chu-Huang (Mendel) Chen, Ming-Hsien Tsai. (ESC Congress, 2023)
  2. Transient receptor potential canonical 7(TRPC7) deficiency restrains high-fat-high-fructose diet (HFHF) induced-aortic damage and aging in mice. Hao Shen, Cheng-Hsu Hsieh, Yun-Fang Liang, Wen-Li Hsu. (2023 The 100th Anniversary Annual Meeting of The Physiological Society of Japan)
  3. A role for STIM1 in regulating abnormal differentiation of epidermis via integrin β4/ERK signaling. Cheng-Hsu Hsieh, Yun-Fang Liang, Wen-Li Hsu, Ching-Ying Wu. (2022 Taiwanese Society for Investigative Dermatology)
  4. Treatment with non-selective transient receptor potential canonical channels inhibitor, Derinat promotes hair regeneration in female pattern hair loss patients. Ching-Ying Wu, Wei-Chiao Chen, Wen-Li Hsu. (2022 Formosa Associated Regenerative Medicine)
  5. Toxic effects of a nematode, Caenorhabditis elegans, exposure to single-walled carbon nanotubes (SWCNTs). Danielle E. Que, Yan-You Gou, Ming-Hsien Tsai, Wen-Li Hsu, Ming-Ching Chung, Wen-Che Hou, How-Ran Chao. (2018 T&T IAC)
  6. Apolipoprotein E -491 gene polymorphism and Alzheimer’s disease: a systematic review and meta-analysis. Wen-Li Hsu, Liang-Yin Ke, Shi-Hui Law, Chu-Huang Chen, Ming-Hsien Tsai. (The 2016 Alzheimer’s Disease Congress)
  7. Projective effects of Derinat against ultraviolet B-induced damage in human keratinocyte ells. Liu J., Fujita K., Wen-Li Hsu, Yoshioka T., Noda M. (2015 Interaction of nervous and immune systems in health and disease)

Ruei-Cheng Yang, Wen-Li Hsu and Tohru Yoshioka. A Novel Concept on the Repetitive Calcium Elevation. New Development in Calcium Signaling Reserch. NOVA publisher. Chapter IV, Page 67-87. Dec, 2013.