HALST專區

HALST計畫

台灣中老年健康因子及健康老化長期研究

Healthy Aging Longitudinal Study in Taiwan(HALST)

在2019年男性的平均壽命達到77.7歲,女性達到84.2歲,由於壽命的延展,台灣的人口逐漸老化,目前65歲以上的人佔全人口的14.1%。這個比率將逐漸增加,在2026年時估計將達到全人口的21.2%。人口老化相繼而來的通常是慢性病及老人症候群的盛行率增加,進而提高國家醫療成本。

本計畫是一個多中心長期追蹤的研究計畫,本研究重視人口老化的公共衛生議題,因此,自2009 年起,於北、中、南、東,共七個地區,針對55 歲以上中老年人進行長期追蹤調查。除了每五至六年一次的家庭訪視與健康檢查外,期間每一年也會利用電話訪視追蹤個案的健康情形與變化。由於本計畫原追蹤世代的年齡層隨著追蹤年數增加而增加,以及個案數因為遷徙、疾病或死亡等因素而流失或減少,為維持本計畫之代表性,故於2023年起建立新的追蹤世代

研究內容包含個人人口學基本變項生活型態飲食運動習慣認知功能精神狀態評估身體活動功能慢性病狀況生化檢查生物標記,以及基因和環境相關因子等,以了解中老年健康老化之生理、心理與社會功能的狀態與相互影響情形。因此規劃延緩老化失能的策略,提供政策參考並促進銀髮族健康。


參考文獻:

圖片來源:Image by pch.vector on Freepik

研究目的

本計畫將可提供政策制定者將資源分配於促進健康生活型態上,以使得老年人能延緩罹病和失能開始的時間,維持高品質的生活並降低醫療成本。

執行重點:
  • 影響中老年人身體功能、衰弱症(含相關疾病狀態)及其變化之因子之研究
  • 健康的生活型態對中老年人心血管及代謝疾病與癌症的預防,以及生活品質與身體活動功能所帶來的益處之研究
  • 中老年人心血管及代謝症候群個人與環境層次之危險因子之研究
  • 中老年人精神疾患之相關因子及其對健康影響之研究
  • 中老年人衰老/成功老化及相關慢性病的生物、遺傳標記與環境因子之研究
  • 建置高齡低劑量斷層掃描(GOLD-CT,Geriatric Observation LDCT)
特點:
  • 參與者具全國城鄉之差異性,長期追蹤超過12年,串聯衛生福利資料科學中心(含健保資料檔、死亡檔、癌登癌篩檔等),各項與健康相關的結果完整、可信度高

研究方法


原追蹤世代:
針對第一期所收錄的55 歲以上中老年人進行長期追蹤調查,每五至六年一次的家庭訪視與健康檢查,各期之間進行三次電話追蹤訪視(每一至二年一次),並串聯衛生福利資料科學中心,追蹤期間發生的醫療服務使用、新發之健康相關事件、死亡等資訊。


新追蹤世代:
依照原追蹤世代的標準作業流程執行,進行長期追蹤調查。

研究對象

原追蹤世代: 長期追蹤5663位北中南東七家醫院附近社區55歲以上中老年人(第一期)


世代建立及追蹤

研究團隊

計畫名稱:台灣中老年健康因子及健康老化長期研究

執行單位:財團法人國家衛生研究院

計畫主持人: 熊昭(第一期、第二期)、 許志成(第三期)

研究團隊(依姓名筆劃排序):
吳其炘吳易謙吳銘庭張新儀莊淑鈞莊紹源陳主智鄭婉汝鍾仁華

規劃期顧問教授(依姓名筆劃排序):
李明瑱梁賡義劉江Dilip V. JesteJack M. GuralnikLuigi Ferrucci

合作醫院(依計畫執行順序排列):
苗栗:梓榮醫療社團法人弘大醫院
嘉義:衛生福利部朴子醫院
楊梅:怡仁綜合醫院
彰化:彰化基督教醫療財團法人彰化基督教醫院
   秀傳醫療社團法人秀傳紀念醫院
花蓮:臺灣基督教門諾會醫療財團法人門諾醫院
高雄:阮綜合醫療社團法人阮綜合醫院
台北:新光醫療財團法人新光吳火獅紀念醫院

研究助理(依姓名筆劃排序):
方耀輝(博士後研究員)、王甄、吳瑞欽、吳翠如、林星妤、林憲志、陳美智、陳惠玲、陳蕾娜、曾暐婷、鄭秋汶、賴玫均、賴萬銓
暨多位曾參與本計畫之工作同仁及訪視人員(略)

研究成果

  1. Liu, Y. T., W. H. Wu, W. T. Tseng, H. C. Lin, M. S. Wu, P. F. Chen and I. C. Wu (2023). "Lower HbA1C of glycemic control is associated with higher risk of depressive symptoms in elderly with type 2 diabetes mellitus-A Nationwide Community-based study." J Psychosom Res 174: 111492.
  2. Chuang, S. C., I. C. Wu, C. A. Hsiung, H. T. Chan, C. W. Cheng, H. L. Chen, Y. F. Chiu, M. M. Lee, H. Y. Chang and C. C. Hsu (2023). "Dietary Inflammatory Patterns Are Associated With Serum TGs and Insulin in Adults: A Community-Based Study in Taiwan." J Nutr 153(6): 1783-1792
  3. Wu, C. S., H. Y. Tseng, C. Y. Lee, I. C. Wu, H. Y. Chang, C. C. Hsu, C. A. Hsiung and Y. F. Chiu (2023). "Interactions of Insomnia and Sedative-Hypnotic Drug Use Associated with Frailty Over Time Among Older Adults." Am J Geriatr Psychiatry 31(6): 438-448.
  4. Wu, I. C., C. S. Liu, W. L. Cheng, T. T. Lin, H. L. Chen, P. F. Chen, R. C. Wu, C. W. Huang, C. A. Hsiung and C. C. Hsu (2022). "Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study." Immun Ageing 19(1): 62.
  5. Chuang, S. C., I. C. Wu, J. J. Chang, Y. F. Tsai, C. W. Cheng, Y. F. Chiu, H. Y. Chang, M. M. Lee, C. C. Hsu and C. A. Hsiung (2022). “Sleep habits are associated with cognition decline in physically robust, but not in frail participants: a longitudinal observational study.” Sci Rep 12(1): 11595.
  6. Chang, C. C., C. S. Wu, H. Y. Tseng, C. Y. Lee, I. C. Wu, C. C. Hsu, H. Y. Chang, Y. F. Chiu and C. A. Hsiung (2022). "Assessment of incident frailty hazard associated with depressive symptoms in a Taiwanese longitudinal study." Int Psychogeriatr 34(1): 61-70.
  7. Lu, T. P., A. Chattopadhyay, K. C. Lu, J. Y. Chuang, S. S. Yeh, I. S. Chang, C. J. Chen, I. C. Wu, C. C. Hsu, T. Y. Chen, W. T. Tseng, C. A. Hsiung and J. J. Juang (2021). "Develop and Apply Electrocardiography-Based Risk Score to Identify Community-Based Elderly Individuals at High-Risk of Mortality." Front Cardiovasc Med 8: 738061.
  8. Chen, C. H., M. S. Wu, Y. W. Yang, Y. T. Liu, Y. F. Chiu, C. C. Hsu, S. C. Chuang, T. C. Chung, T. L. Tsai, W. H. Huang, W. L. Huang, C. C. Juan, L. M. Lien, C. A. Hsiung and I. C. Wu (2021). “Longitudinal changes in physical and mental health of older adults with chronic hepatitis B infection: Trajectories and predictors.” Prev Med Rep 23: 101432.
  9. Guo, S. M., Y. T. Liu, S. R. He, M. S. Wu, W. T. Tseng, R. C. Wu and I. C. Wu (2021). "Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study." Aging (Albany NY) 13(7): 10555-10583
  10. Juang, J. J., Y. J. Huang, I. S. Chang, C. J. Chen, I. C. Wu, C. C. Hsu, T. Y. Chen, W. T. Tseng, S. S. Yeh and C. A. Hsiung (2020). "Role of electrocardiographic early repolarization pattern in long-term outcomes of a community-based middle-aged and geriatric ambulatory population: a prospective cohort study." Aging (Albany NY) 12(24): 26140-26187.
  11. Yeh, S. S., C. J. Chen, I. C. Wu, C. C. Hsu, T. Y. Chen, W. T. Tseng, F. C. Tang, C. C. Wang, C. C. Juan, H. C. Chiu, H. M. Lo, D. H. Yang, J. J. Juang and C. A. Hsiung (2020). "The 10-Year Prognosis and Prevalence of Brugada-Type Electrocardiograms in Elderly Women: A Longitudinal Nationwide Community-Based Prospective Study." J Cardiovasc Nurs 35(6): E25-E32.
  12. Yeh, S. S., C. J. Chen, I. C. Wu, C. C. Hsu, T. Y. Chen, W. T. Tseng, F. C. Tang, C. C. Wang, C. C. Juan, H. C. Chiu, H. M. Lo, D. H. Yang, J. J. Juang and C. A. Hsiung (2020). "Prognostic value and prevalence of complete right bundle branch block in an elderly population: a community-based 10-year prospective study." Aging (Albany NY) 12(19): 19073-19082.
  13. Tseng, H. Y., C. Lockenhoff, C. Y. Lee, S. H. Yu, I. C. Wu, H. Y. Chang, Y. F. Chiu and C. A. Hsiung (2020). "The paradox of aging and health-related quality of life in Asian Chinese: results from the Healthy Aging Longitudinal Study in Taiwan." BMC Geriatr 20(1): 91.
  14. Wu, I. C., C. C. Hsu, C. Y. Chen, S. C. Chuang, C. W. Cheng, W. S. Hsieh, M. S. Wu, Y. T. Liu, Y. H. Liu, T. L. Tsai, C. C. Lin and C. A. Hsiung (2019). "Paradoxical Relationship Between Glycated Hemoglobin and Longitudinal Change in Physical Functioning in Older Adults: A Prospective Cohort Study." J Gerontol A Biol Sci Med Sci 74(6): 949-956.
  15. Hsieh, T. J., H. Y. Chang, I. C. Wu, C. C. Chen, H. J. Tsai, Y. F. Chiu, S. C. Chuang, C. A. Hsiung and C. C. Hsu (2018). "Independent association between subjective cognitive decline and frailty in the elderly." PLoS One 13(8): e0201351.
  16. Chen, C. H., M. S. Wu and I. C. Wu (2018). "Vaccination coverage and associated factors for receipt of the 23-valent pneumococcal polysaccharide vaccine in Taiwan: A nation-wide community-based study." Medicine (Baltimore) 97(5): e9773.
  17. Ko, K. T., S. H. Yu, C. Y. Lee, H. Y. Tseng, Y. F. Chiu and C. A. Hsiung (2018). "Moderating effect of depression on the association between pain and activities of daily living in older adults." Psychogeriatrics 18(5): 379-387.
  18. Tseng, H. Y., S. H. Yu, C. Y. Lee, W. H. Huang, S. L. Huang, C. S. Wu, Y. F. Chiu and C. A. Hsiung (2018). “Sedative-hypnotic drug use among community-dwelling elderly in Taiwan.” Int Psychogeriatr 30(7): 957-965.
  19. Chen, C. J., J. J. Juang, Y. H. Chen, I. C. Wu, C. C. Hsu, R. C. Wu, K. C. Chen, W. J. Liaw, T. L. Tsai, L. Y. Lin, J. J. Hwang, L. T. Ho, C. C. Yu, J. K. Lee, C. K. Wu, S. S. Yeh, D. H. Yang, I. S. Chang, L. P. Lai, F. T. Chiang, J. L. Lin and C. A. Hsiung (2018). “Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study.” Ann Med 50(1): 7-15.
  20. Chen, C. H., M. S. Wu, W. Y. Hsu, Y. M. Chen, C. C. Hsu, C. A. Hsiung and I. C. Wu (2017). "Determinants of influenza vaccination in older adults: A nationwide community-based study in Taiwan." Geriatr Gerontol Int 17(12): 2396-2402.
  21. Hsu, C. C., H. Y. Chang, I. C. Wu, C. C. Chen, H. J. Tsai, Y. F. Chiu, S. C. Chuang, W. C. Hsiung, T. L. Tsai, W. J. Liaw, I. C. Lin, S. C. Shen, C. C. Juan, L. M. Lien, M. Lee, Y. I. Chen, K. Liu and C. A. Hsiung (2017). "Cohort Profile: The Healthy Aging Longitudinal Study in Taiwan (HALST)." Int J Epidemiol 46(4): 1106-1106j.
  22. Wu, I. C., C. C. Lin, C. S. Liu, C. C. Hsu, C. Y. Chen and C. A. Hsiung (2017). "Interrelations Between Mitochondrial DNA Copy Number and Inflammation in Older Adults." J Gerontol A Biol Sci Med Sci 72(7): 937-944.
  23. Wu, C. S., S. H. Yu, C. Y. Lee, H. Y. Tseng, Y. F. Chiu and C. A. Hsiung (2017). "Prevalence of and risk factors for minor and major depression among community-dwelling older adults in Taiwan." Int Psychogeriatr 29(7): 1113-1121.
  24. Chen, C. C., K. Liu, C. C. Hsu, H. Y. Chang, H. C. Chung, J. S. Liu, Y. H. Liu, T. L. Tsai, W. J. Liaw, I. C. Lin, H. W. Wu, C. C. Juan, H. C. Chiu, M. M. Lee and C. A. Hsiung (2017). "Healthy lifestyle and normal waist circumference are associated with a lower 5-year risk of type 2 diabetes in middle-aged and elderly individuals: Results from the healthy aging longitudinal study in Taiwan (HALST)." Medicine (Baltimore) 96(6): e6025.
  25. Chuang, S. C., H. L. Chen, W. T. Tseng, I. C. Wu, C. C. Hsu, H. Y. Chang, Y. I. Chen, M. M. Lee, K. Liu and C. A. Hsiung (2016). "Circulating 25-hydroxyvitamin D and physical performance in older adults: a nationwide study in Taiwan." Am J Clin Nutr 104(5): 1334-1344.
  26. Hsu, W. Y., H. J. Tsai, S. H. Yu, C. C. Hsu, Y. T. Tsai, H. Y. Tzeng, I. C. Lin, K. Liu, M. M. Lee, N. Y. Chiu and C. A. Hsiung (2016). "Association of depression and psychotropic medication on cardiac-related outcomes in a nationwide community-dwelling elderly population in Taiwan." Medicine (Baltimore) 95(31): e4419.
  27. Ehret, G. B., … I. S. Chang, C. Y. Cheng, … R. H. Chung, … C. A. Hsiung, …C. Newton-Cheh and P. B. Munroe (2016). “The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.” Nat Genet 48(10): 1171-1184.
  28. Assimes, T. L., I. T. Lee, J. M. Juang, X. Guo, T. D. Wang, E. T. Kim, W. J. Lee, D. Absher, Y. F. Chiu, C. C. Hsu, L. M. Chuang, T. Quertermous, C. A. Hsiung, J. I. Rotter, W. H. Sheu, Y. D. Chen and K. D. Taylor (2016). "Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi" PLoS One 11(3): e0138014.
  29. Juang, J. M., C. Y. Chen, Y. H. Chen, I. C. Wu, C. C. Hsu, L. N. Chen, F. C. Tang, C. C. Wang, C. C. Juan, H. C. Chiu, H. M. Lo, I. S. Chang, J. J. Hwang, L. P. Lai, F. T. Chiang, J. L. Lin and C. A. Hsiung (2015). "Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: a nation-wide community-based study (HALST cohort)." Europace 17 Suppl 2: ii54-62.
  30. Li, C. I., T. C. Li, W. Y. Lin, C. S. Liu, C. C. Hsu, C. A. Hsiung, C. Y. Chen, K. C. Huang, C. H. Wu, C. Y. Wang, C. C. Lin, Sarcopenia and T. Translational Aging Research in Taiwan (2015). "Combined association of chronic disease and low skeletal muscle mass with physical performance in older adults in the Sarcopenia and Translational Aging Research in Taiwan (START) study." BMC Geriatr 15: 11.
  31. Knowles, J. W., …Y. D. Chen,…C. A. Hsiung, …M. Walker and T. Quertermous (2015). "Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene." J Clin Invest 125(4): 1739-1751.
  32. Wu, Y., …Y. F. Chiu, …C. A. Hsiung, …Mohlke and E. S. Tai (2014). “A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.” Hum Mol Genet 23(4): 1108-1119.
  33. Chen, P., …C. H. Chen, …C. A. Hsiung, … Y. D. Chen, … N. Kato and E. S. Tai (2014). "Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians." Diabetes 63(7): 2551-2562.
  34. Wen, W.,…C. C. Chen, …C. H. Chen, …C. A. Hsiung, I. C. Wu, … Y. D. Chen, … X. O. Shu and T. Tanaka (2014). "Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index." Hum Mol Genet 23(20): 5492-5504.
  35. Wu, I. C., C. C. Lin, C. A. Hsiung, C. Y. Wang, C. H. Wu, D. C. Chan, T. C. Li, W. Y. Lin, K. C. Huang, C. Y. Chen, C. C. Hsu, Sarcopenia and T. Translational Aging Research in Taiwan (2014). “Epidemiology of sarcopenia among community-dwelling older adults in Taiwan: a pooled analysis for a broader adoption of sarcopenia assessments.” Geriatr Gerontol Int 14 Suppl 1: 52-60.
  36. Miller, C. L., D. R. Anderson, R. K. Kundu, A. Raiesdana, S. T. Nurnberg, R. Diaz, K. Cheng, N. J. Leeper, C. H. Chen, I. S. Chang, E. E. Schadt, C. A. Hsiung, T. L. Assimes and T. Quertermous (2013). "Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus." PLoS Genet 9(7): e1003652.
  37. Wu, Y.,… W. C. Wang, ... Y. D. Chen,…C. H. Chen, I. S. Chang, E. E. Schadt, C. A. Hsiung, T. L. Assimes and T. Quertermous (2013). "Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained." PLoS Genet 9(3): e1003379.
  38. Willer, C. J.,… H. Y. Chang,… C. A. Hsiung, …G. R. Abecasis and C. Global Lipids Genetics (2013). "Discovery and refinement of loci associated with lipid levels." Nat Genet 45(11): 1274-1283.
  39. Do, R., … H. Y. Chang, … Y. D. Chen, … C. A. Hsiung,…B. M. Neale and S. Kathiresan (2013). "Common variants associated with plasma triglycerides and risk for coronary artery disease." Nat Genet 45(11): 1345-1352.
  40. Kuo, J. Z., W. H. Sheu, T. L. Assimes, Y. J. Hung, D. Absher, Y. F. Chiu, J. Mak, J. S. Wang, S. Kwon, C. C. Hsu, M. O. Goodarzi, I. T. Lee, J. W. Knowles, B. E. Miller, W. J. Lee, J. M. Juang, T. D. Wang, X. Guo, K. D. Taylor, L. M. Chuang, C. A. Hsiung, T. Quertermous, J. I. Rotter and Y. D. Chen (2013). "Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population." Diabetologia 56(12): 2619-2628.
  41. Wu, I. C., H. Y. Chang, C. C. Hsu, Y. F. Chiu, S. H. Yu, Y. F. Tsai, S. C. Shen, K. N. Kuo, C. Y. Chen, K. Liu, M. M. Lee and C. A. Hsiung (2013). "Association between dietary fiber intake and physical performance in older adults: a nationwide study in Taiwan." PLoS One 8(11): e80209.

聯絡資訊

單位 :財團法人國家衛生研究院 群體健康科學研究所

地址 :苗栗縣竹南鎮科研路35號 行政大樓A2150室

電話 :(037) 206166 分機36154

E-mail : halst@nhri.edu.tw

圖片來源:Image by felicities on Freepik